PF3D7_0720900

Genome location: Pf3D7_07_v3:901,363..903,408(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.37	0.77
Schizont	expressed	0.10	0.93
Gametocyte	possibly expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0720900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.984 | MFS: -1.824 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0618400)

Relative Growth Rate: 1.00 ± 0.17
Confidence: 4.93

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0618400)

Modification: Disrupted | RMgm-2140

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWF7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532393

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	5	4	11
disruptive	14	15	5	24
missense	3	8	5	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	13	8	17
disruptive	21	35	21	38
missense	4	20	17	27

PlasmoDB Total SNPs: 198

Non-coding: 139 | Synonymous: 16 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 265 | Molecular Weight (kDa): 31.126

UniProt ID(s): A0A143ZWF7

PDB ID(s): None

Isoelectric Point: 5.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily