PF3D7_0721000

Genome location: Pf3D7_07_v3:903,558..914,883(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.59	0.74
Trophozoite	expressed	1.69	0.29
Schizont	expressed	1.48	0.35
Gametocyte	expressed	1.45	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 7 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.221 | MFS: -2.698 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532571

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	131	77	172
disruptive	249	521	284	613
missense	103	309	198	429

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	45	267	113	205
disruptive	428	1054	416	876
missense	161	649	301	578

PlasmoDB Total SNPs: 788

Non-coding: 121 | Synonymous: 308 | Nonsynonymous: 340 | Stop Codon: 19

Protein Information

Protein Length: 3459 | Molecular Weight (kDa): 420.421

UniProt ID(s): A0A143ZWQ6

PDB ID(s): None

Isoelectric Point: 8.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR038841	Uncharacterized protein PF07_0086
PFam	N/A	N/A
Superfamily	N/A	N/A