About Gene List

PF3D7_0721100

Genome location: Pf3D7_07_v3:915,483..917,854(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MSRLFSFLFFCLIIVFFSSSFVFSRG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0071944 cell periphery
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.20 0.91
Trophozoite expressed 1.53 0.32
Schizont expressed 0.29 0.84
Gametocyte expressed 0.64 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.967 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0618600)

  • Relative Growth Rate: 0.13 ± 0.14
  • Confidence: 5.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0621300)

Modification: Tagged | RMgm-1514

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBP0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134695

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 216

Non-coding: 205 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 244 | Molecular Weight (kDa): 29.25

UniProt ID(s): Q8IBP0

PDB ID(s): None

Isoelectric Point: 8.69

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27503796 Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. Siau A, Huang X, ..., Preiser PR 10.1038/srep31055
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33515807 Systematic Identification of Plasmodium Falciparum Sporozoite Membrane ProteinInteractions Reveals an Essential Role for the p24 Complex in Host Infection. Knockel J, Dundas K, ..., Wright GJ 10.1074/mcp.RA120.002432