PF3D7_0721200

Genome location: Pf3D7_07_v3:917,535..921,058(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.23	0.88
Trophozoite	not expressed	0.19	0.88
Schizont	not expressed	0.13	0.91
Gametocyte	not expressed	0.32	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.401 | MFS: -2.496 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0618700)

Relative Growth Rate: 0.08 ± 0.69
Confidence: 2.13

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBN9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532581

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	37	18	45
disruptive	56	131	83	167
missense	29	99	62	131

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	72	35	59
disruptive	88	296	126	288
missense	45	211	88	184

PlasmoDB Total SNPs: 175

Non-coding: 55 | Synonymous: 76 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 952 | Molecular Weight (kDa): 114.02

UniProt ID(s): Q8IBN9

PDB ID(s): None

Isoelectric Point: 8.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A