PF3D7_0721400

Genome location: Pf3D7_07_v3:925,872..928,510(+)

Genome classification: Core

Function and Localization

Product Description: rhoptry protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020008	rhoptry

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.47	0.71
Schizont	expressed	0.15	0.89
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.166 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBN7

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=1.84) with 4KVJ (Global RMSD=23.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130832

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	1	9
disruptive	2	10	6	10
missense	2	10	6	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	11	7	22
disruptive	2	23	22	42
missense	2	18	20	31

PlasmoDB Total SNPs: 217

Non-coding: 212 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 24.792

UniProt ID(s): Q8IBN7

PDB ID(s): None

Isoelectric Point: 7.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036412	HAD-like superfamily
PFam	N/A	N/A
Superfamily	SSF56784	HAD-like superfamily