PF3D7_0721500

Genome location: Pf3D7_07_v3:928,514..931,139(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016021	integral component of membrane
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.35	0.80
Schizont	possibly expressed	0.14	0.91
Gametocyte	expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.167 | MFS: -2.777 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533266

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	30	16	44
disruptive	17	80	64	136
missense	15	65	54	123

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	66	28	41
disruptive	49	220	102	223
missense	24	167	80	157

PlasmoDB Total SNPs: 111

Non-coding: 16 | Synonymous: 50 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 779 | Molecular Weight (kDa): 94.975

UniProt ID(s): Q8IBN6

PDB ID(s): None

Isoelectric Point: 9.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A