Product Description: 40S ribosomal protein S5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0019843 | rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000028 | ribosomal small subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.23 | 0.48 |
| Trophozoite | expressed | 1.37 | 0.36 |
| Schizont | expressed | 0.32 | 0.80 |
| Gametocyte | expressed | 0.62 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0721600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.873 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0619100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBN5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100920
Most Similar Human Ortholog: M0R0R2
TM-align score: 0.99 | RMSD: 0.65
Seq Identity: 0.73 | Length: 195 / 195
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000083845 | ribosomal protein S5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 4 | 4 | 11 |
| disruptive | 0 | 4 | 3 | 10 |
| missense | 0 | 4 | 3 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 6 | 14 |
| disruptive | 0 | 17 | 21 | 42 |
| missense | 0 | 14 | 18 | 36 |
PlasmoDB Total SNPs: 141
Non-coding: 135 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 195 | Molecular Weight (kDa): 21.863
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000235 | Ribosomal protein S5/S7 |
| InterPro | IPR005716 | Ribosomal protein S5/S7, eukaryotic/archaeal |
| InterPro | IPR020606 | Ribosomal protein S7, conserved site |
| InterPro | IPR023798 | Ribosomal protein S7 domain |
| InterPro | IPR036823 | Ribosomal protein S7 domain superfamily |
| PFam | PF00177 | Ribosomal protein S7 domain |
| Superfamily | SSF47973 | Ribosomal protein S7 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |