PF3D7_0721700 (PSOP1)

Genome location: Pf3D7_07_v3:935,116..937,312(+)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MNKLLLFCLFLYSVVA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020009	microneme

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.882 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0619200)

Relative Growth Rate: 0.84 ± 0.15
Confidence: 5.22

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0619200)

Modification: Disrupted | RMgm-2144

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533324

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	16	11	44
disruptive	5	22	16	45
missense	5	22	15	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	36	27	43
disruptive	8	56	30	102
missense	7	51	27	79

PlasmoDB Total SNPs: 72

Non-coding: 50 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 467 | Molecular Weight (kDa): 53.286

UniProt ID(s): Q8IBN4

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
34147682	PSOP1, putative secreted ookinete protein 1, is localized to the micronemes ofPlasmodium yoelii and P. berghei ookinetes.	Tachibana M, Iriko H, ..., Ishino T	10.1016/j.parint.2021.102407
34869075	Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressedin Mature P. falciparum Gametocytes	Muthui MK, Takashima E, ..., Kapulu MC	10.3389/fcimb.2021.774537