PF3D7_0721900

Genome location: Pf3D7_07_v3:939,284..941,111(-)

Genome classification: Core

Function and Localization

Product Description: V-type ATPase V0 subunit e, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0055085	transmembrane transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.06	0.97
Trophozoite	no data	0.08	0.95
Schizont	no data	0.10	0.94
Gametocyte	no data	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0721900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.208 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4P0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102348

Most Similar Human Ortholog: Q8NHE4

TM-align score: 0.65 | RMSD: 2.57

Seq Identity: 0.21 | Length: 66 / 78

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000113732	ATPase H+ transporting V0 subunit e1
ENSG00000171130	ATPase H+ transporting V0 subunit e2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 90

Non-coding: 85 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 78 | Molecular Weight (kDa): 9.284

UniProt ID(s): C0H4P0

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008389	ATPase, V0 complex, subunit e1/e2
PFam	PF05493	ATPase, V0 complex, subunit e1/e2
Superfamily	N/A	N/A