PF3D7_0722300

Genome location: Pf3D7_07_v3:948,774..953,832(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin carboxyl-terminal hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.4.19.12 (Ubiquitinyl hydrolase 1)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.47	0.77
Trophozoite	expressed	0.48	0.72
Schizont	expressed	0.15	0.90
Gametocyte	expressed	0.72	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.722 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBN0

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=38.77) with 7WYF (Global RMSD=30.48)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.4.19.12	ubiquitinyl hydrolase 1	KClNEMDTTEDTAEGTARNAisiRNApeptidesAntibodyubiquitinLDN-574442-propenal...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532410

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	53	27	71
disruptive	50	143	68	189
missense	18	105	47	154

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	88	58	68
disruptive	88	295	120	252
missense	34	200	90	166

PlasmoDB Total SNPs: 269

Non-coding: 76 | Synonymous: 119 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 1221 | Molecular Weight (kDa): 145.492

UniProt ID(s): Q8IBN0

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001607	Zinc finger, UBP-type
PFam	PF02148	Zinc finger, UBP-type
Superfamily	SSF57850	N/A