Product Description: Obg-like ATPase 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.1.1.3 (Threonine--tRNA ligase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0005525 | GTP binding |
| Process | GO:0007165 | signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.69 | 0.67 |
| Trophozoite | expressed | 1.10 | 0.44 |
| Schizont | expressed | 0.17 | 0.89 |
| Gametocyte | not expressed | 0.25 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0722400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.921 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBM9
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.65) with 2DBY (Global RMSD=2.81)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.1.1.3 | threonine-tRNA ligase | borrelidinthreonyl-AMPZINC27215482ZINC67910544ZINC72320615ZINC72320626ZINC35270978ZINC35458951hydrogen peroxideoperator mRNA domain 2tubercidin 5'-triphosphatePurineriboside 5'-triphosphate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100571
Most Similar Human Ortholog: Q9NTK5
TM-align score: 0.94 | RMSD: 1.79
Seq Identity: 0.54 | Length: 385 / 393
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138430 | Obg like ATPase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 16 | 6 | 31 |
| disruptive | 0 | 2 | 6 | 20 |
| missense | 0 | 2 | 5 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 34 | 11 | 23 |
| disruptive | 3 | 17 | 18 | 44 |
| missense | 0 | 10 | 18 | 37 |
PlasmoDB Total SNPs: 63
Non-coding: 53 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 393 | Molecular Weight (kDa): 45.164
UniProt ID(s): Q8IBM9
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004396 | Ribosome-binding ATPase YchF/Obg-like ATPase 1 |
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR012676 | TGS-like |
| InterPro | IPR013029 | YchF, C-terminal domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR041706 | YchF, N-terminal |
| PFam | PF01926 | GTP binding domain |
| PFam | PF06071 | YchF, C-terminal domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF81271 | TGS-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34122627 | OLA1 is a potential prognostic molecular biomarker for endometrial cancer andpromotes tumor progression | Dong Y, Yin A, ..., Guo S | 10.3892/ol.2021.12837 |
| 35134491 | BARD1 is an ATPase activating protein for OLA1 | Chen T, Yeh HW, ..., Cheng HC | 10.1016/j.bbagen.2022.130099 |
| 34571008 | Quantitative proteomics identifies the universally conserved ATPase Ola1p as apositive regulator of heat shock response in Saccharomyces cerevisiae | Dannenmaier S, Desroches Altamirano C, ..., Warscheid B | 10.1016/j.jbc.2021.101050 |