About Gene List

PF3D7_0722500 (CWC15)

Genome location: Pf3D7_07_v3:956,747..958,325(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor CWC15, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005684 U2-type spliceosomal complex
Component GO:0071013 catalytic step 2 spliceosome
Component GO:0005681 spliceosomal complex
Function GO:0003723 RNA binding
Process GO:0008380 RNA splicing
Process GO:0045292 mRNA cis splicing, via spliceosome
Process GO:0000398 mRNA splicing, via spliceosome
Process GO:0051726 regulation of cell cycle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.38 0.82
Trophozoite expressed 0.38 0.77
Schizont expressed 0.13 0.91
Gametocyte expressed 0.69 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.784 | MFS: -1.881 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102825

Most Similar Human Ortholog: Q9P013

TM-align score: 0.46 | RMSD: 4.05

Seq Identity: 0.35 | Length: 136 / 291

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000150316 CWC15 spliceosome associated protein homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 15 8 18
disruptive 10 28 20 42
missense 2 21 18 30

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 32 6 16
disruptive 24 65 26 62
missense 7 51 21 42

PlasmoDB Total SNPs: 87

Non-coding: 56 | Synonymous: 23 | Nonsynonymous: 7 | Stop Codon: 1

Protein Information

Protein Length: 291 | Molecular Weight (kDa): 34.15

UniProt ID(s): Q8IBM8

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006973 Pre-mRNA-splicing factor Cwf15/Cwc15
PFam PF04889 Pre-mRNA-splicing factor Cwf15/Cwc15
Superfamily N/A N/A

Associated Publications

No associated publications