PF3D7_0722600 (UTP7)

Genome location: Pf3D7_07_v3:958,352..961,340(-)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0030688	preribosome, small subunit precursor
Component	GO:0032040	small-subunit processome
Process	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.03	0.55
Trophozoite	expressed	0.79	0.58
Schizont	expressed	0.52	0.69
Gametocyte	expressed	0.81	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.245 | MFS: -2.718 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM7

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.62) with 4GM8 (Global RMSD=4.45)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102360

Most Similar Human Ortholog: A0A140T9L0

TM-align score: 0.81 | RMSD: 2.63

Seq Identity: 0.27 | Length: 285 / 602

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000204221	WD repeat domain 46
ENSG00000206284	WD repeat domain 46
ENSG00000226916	WD repeat domain 46
ENSG00000227057	WD repeat domain 46
ENSG00000236222	WD repeat domain 46

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	22	15	25
disruptive	10	44	47	61
missense	8	29	37	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	59	25	26
disruptive	29	114	49	115
missense	19	82	40	81

PlasmoDB Total SNPs: 180

Non-coding: 112 | Synonymous: 49 | Nonsynonymous: 17 | Stop Codon: 2

Protein Information

Protein Length: 602 | Molecular Weight (kDa): 70.187

UniProt ID(s): Q8IBM7

PDB ID(s): None

Isoelectric Point: 9.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR012952	BING4, C-terminal domain
InterPro	IPR036322	WD40-repeat-containing domain superfamily
InterPro	IPR040315	WD repeat-containing protein WDR46/Utp7
PFam	PF08149	BING4, C-terminal domain
Superfamily	SSF50978	WD40-repeat-containing domain superfamily