PF3D7_0722700 (C3AP1)

Genome location: Pf3D7_07_v3:961,629..963,030(+)

Genome classification: Core

Function and Localization

Product Description: respiratory chain complex 3 associated protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005750	mitochondrial respiratory chain complex III
Component	GO:0005739	mitochondrion
Process	GO:0034551	mitochondrial respiratory chain complex III assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.01	0.99
Trophozoite	expressed	0.05	0.96
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.163 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0620200)

Relative Growth Rate: 0.08 ± 0.10
Confidence: 6.08

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179333

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 63

Non-coding: 61 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 1

Protein Information

Protein Length: 79 | Molecular Weight (kDa): 9.502

UniProt ID(s): Q8IBM6

PDB ID(s): None

Isoelectric Point: 10.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
33524071	Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex inToxoplasma gondii parasites.	Hayward JA, Rajendran E, ..., van Dooren GG	10.1371/journal.ppat.1009211
34155201	Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum.	Evers F, Cabrera-Orefice A, ..., Kooij TWA	10.1038/s41467-021-23919-x
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21