PF3D7_0722800

Genome location: Pf3D7_07_v3:963,370..965,109(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MRLDLFLLFCVSPCLYTFFVKG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.04	0.98
Gametocyte	expressed	0.96	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.575 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0620300)

Relative Growth Rate: 1.07 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0620300)

Modification: Disrupted | RMgm-2149

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM5

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=1.86) with 7CDW (Global RMSD=24.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139453

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	24	16	35
disruptive	3	37	19	68
missense	3	36	18	66

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	46	30	45
disruptive	8	75	42	110
missense	6	65	35	82

PlasmoDB Total SNPs: 25

Non-coding: 0 | Synonymous: 19 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 579 | Molecular Weight (kDa): 66.302

UniProt ID(s): Q8IBM5

PDB ID(s): None

Isoelectric Point: 8.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A