PF3D7_0722900

Genome location: Pf3D7_07_v3:965,664..968,075(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	possibly expressed	0.02	0.99
Schizont	possibly expressed	0.21	0.86
Gametocyte	expressed	0.56	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0722900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.666 | MFS: -2.366 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532986

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	18	10	21
disruptive	1	19	11	35
missense	1	19	9	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	29	15	18
disruptive	11	36	17	51
missense	4	33	16	41

PlasmoDB Total SNPs: 180

Non-coding: 171 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 312 | Molecular Weight (kDa): 36.863

UniProt ID(s): Q8IBM4

PDB ID(s): None

Isoelectric Point: 10.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A