PF3D7_0723100 (CPH1)

Genome location: Pf3D7_07_v3:970,492..971,877(-)

Genome classification: Core

Function and Localization

Product Description: protein CPH1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0045177	apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.08	0.94
Gametocyte	expressed	0.36	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.424 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139452

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	15	11	11
disruptive	8	37	29	52
missense	8	33	27	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	21	17	21
disruptive	23	79	36	84
missense	14	66	31	62

PlasmoDB Total SNPs: 30

Non-coding: 0 | Synonymous: 24 | Nonsynonymous: 4 | Stop Codon: 2

Protein Information

Protein Length: 461 | Molecular Weight (kDa): 55.205

UniProt ID(s): Q8IBM2

PDB ID(s): None

Isoelectric Point: 9.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A