PF3D7_0723200

Genome location: Pf3D7_07_v3:972,658..974,272(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKMKKIIIFVLFYFITPKLC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.885 | MFS: -1.844 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0620700)

Relative Growth Rate: 0.84 ± 0.31
Confidence: 3.73

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0620700)

Modification: Disrupted | RMgm-4221

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119622

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	8	23
disruptive	2	12	8	25
missense	2	12	8	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	35	20	24
disruptive	5	33	21	71
missense	3	25	18	59

PlasmoDB Total SNPs: 43

Non-coding: 35 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 358 | Molecular Weight (kDa): 41.027

UniProt ID(s): Q8IBM1

PDB ID(s): None

Isoelectric Point: 7.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
PFam	PF13385	N/A
Superfamily	SSF49899	Concanavalin A-like lectin/glucanase domain superfamily