About Gene List

PF3D7_0723300

Genome location: Pf3D7_07_v3:975,585..978,720(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.09 0.95
Trophozoite expressed 0.25 0.85
Schizont expressed 1.16 0.46
Gametocyte expressed 1.23 0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.792 | MFS: -2.426 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBM0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126635

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 22 13 32
disruptive 21 74 46 109
missense 12 58 40 81

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 44 21 30
disruptive 47 169 56 149
missense 27 128 43 89

PlasmoDB Total SNPs: 239

Non-coding: 29 | Synonymous: 158 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 880 | Molecular Weight (kDa): 101.137

UniProt ID(s): Q8IBM0

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24841368 Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. Butler CL, Lucas O, ..., White M 10.1371/journal.pone.0097625