PF3D7_0723500

Genome location: Pf3D7_07_v3:984,384..985,928(-)

Genome classification: Core

Function and Localization

Product Description: dynactin subunit 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005869	dynactin complex
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.599 | MFS: -2.327 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBL8

"Best" AlphaFill ligand hit: BU1 (1,4-butanediol, Local RMSD=0.04) with 3NZ2 (Global RMSD=4.24)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103929

Most Similar Human Ortholog: Q9BTE1

TM-align score: 0.96 | RMSD: 1.37

Seq Identity: 0.36 | Length: 182 / 226

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000166847	dynactin subunit 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	8	20
disruptive	3	8	8	34
missense	3	8	8	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	24	12	24
disruptive	6	26	32	86
missense	6	26	25	55

PlasmoDB Total SNPs: 87

Non-coding: 73 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 226 | Molecular Weight (kDa): 25.684

UniProt ID(s): Q8IBL8

PDB ID(s): None

Isoelectric Point: 8.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001451	Hexapeptide repeat
InterPro	IPR011004	Trimeric LpxA-like superfamily
PFam	PF00132	Hexapeptide repeat
Superfamily	SSF51161	Trimeric LpxA-like superfamily