PF3D7_0723600

Genome location: Pf3D7_07_v3:986,292..987,765(+)

Genome classification: Core

Function and Localization

Product Description: proteasome assembly chaperone 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.08	0.95
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -3.433 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0621100)

Relative Growth Rate: 0.13 ± 0.12
Confidence: 5.56

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBL7

"Best" AlphaFill ligand hit: UTP (uridine 5'-triphosphate, Local RMSD=5.03) with 7X4P (Global RMSD=15.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105203

Most Similar Human Ortholog: Q5JS54

TM-align score: 0.81 | RMSD: 1.97

Seq Identity: 0.17 | Length: 112 / 149

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000180822	proteasome assembly chaperone 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	1	9
disruptive	1	15	12	14
missense	1	15	12	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	6	5	9
disruptive	5	31	17	32
missense	5	29	15	27

PlasmoDB Total SNPs: 127

Non-coding: 106 | Synonymous: 13 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 149 | Molecular Weight (kDa): 17.711

UniProt ID(s): Q8IBL7

PDB ID(s): None

Isoelectric Point: 4.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR032157	Proteasome assembly chaperone 4
PFam	PF16093	Proteasome assembly chaperone 4
Superfamily	N/A	N/A