Genome location: Pf3D7_07_v3:991,989..1,000,332(+)
Genome classification: Core
Product Description: apicomplexan kinetochore protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
| Function | GO:0050699 | WW domain binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 1.19 | 0.44 |
| Schizont | expressed | 2.03 | 0.22 |
| Gametocyte | expressed | 1.32 | 0.37 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0723800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.004 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_0624000)
Modification: Tagged | RMgm-5308
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBL5
"Best" AlphaFill ligand hit: OLB ((2s)-2,3-dihydroxypropyl (9z)-octadec-9-enoate, Local RMSD=0.05) with 5T77 (Global RMSD=18.70)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 86 | 49 | 104 |
| disruptive | 82 | 220 | 101 | 327 |
| missense | 38 | 150 | 82 | 243 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 162 | 73 | 132 |
| disruptive | 154 | 470 | 210 | 550 |
| missense | 68 | 314 | 158 | 316 |
PlasmoDB Total SNPs: 515
Non-coding: 193 | Synonymous: 190 | Nonsynonymous: 132 | Stop Codon: 0
Protein Length: 2190 | Molecular Weight (kDa): 260.767
UniProt ID(s): Q8IBL5
PDB ID(s): None
Isoelectric Point: 5.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |