PF3D7_0723900

Genome location: Pf3D7_07_v3:1,000,342..1,005,611(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003729	mRNA binding
Function	GO:0003676	nucleic acid binding
Process	GO:0000398	mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.42	0.80
Trophozoite	possibly expressed	0.84	0.55
Schizont	expressed	0.33	0.79
Gametocyte	not expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.763 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0621400)

Relative Growth Rate: 0.79 ± 0.24
Confidence: 4.22

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0621400)

Modification: Disrupted | RMgm-2152

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBL4

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.01) with 2BVL (Global RMSD=25.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171493

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	46	24	72
disruptive	42	152	89	222
missense	20	131	80	190

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	111	40	103
disruptive	76	363	201	416
missense	40	286	149	277

PlasmoDB Total SNPs: 260

Non-coding: 153 | Synonymous: 64 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1222 | Molecular Weight (kDa): 144.628

UniProt ID(s): Q8IBL4

PDB ID(s): None

Isoelectric Point: 6.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
27381095	The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum.	Bunnik EM, Batugedara G, ..., Le Roch KG	10.1186/s13059-016-1014-0