Product Description: RNA-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005634 | nucleus |
Function | GO:0003729 | mRNA binding |
Function | GO:0003676 | nucleic acid binding |
Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.42 | 0.80 |
Trophozoite | possibly expressed | 0.84 | 0.55 |
Schizont | expressed | 0.33 | 0.79 |
Gametocyte | not expressed | 0.67 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0723900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.763 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0621400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0621400)
Modification: Disrupted | RMgm-2152
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBL4
"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.01) with 2BVL (Global RMSD=25.05)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 46 | 24 | 72 |
disruptive | 42 | 152 | 89 | 222 |
missense | 20 | 131 | 80 | 190 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 14 | 111 | 40 | 103 |
disruptive | 76 | 363 | 201 | 416 |
missense | 40 | 286 | 149 | 277 |
PlasmoDB Total SNPs: 260
Non-coding: 153 | Synonymous: 64 | Nonsynonymous: 43 | Stop Codon: 0
Protein Length: 1222 | Molecular Weight (kDa): 144.628
UniProt ID(s): Q8IBL4
PDB ID(s): None
Isoelectric Point: 6.59
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000504 | RNA recognition motif domain |
InterPro | IPR035979 | RNA-binding domain superfamily |
PFam | PF00076 | RNA recognition motif domain |
Superfamily | SSF54928 | RNA-binding domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |