About Gene List

PF3D7_0723900

Genome location: Pf3D7_07_v3:1,000,342..1,005,611(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0003729 mRNA binding
Function GO:0003676 nucleic acid binding
Process GO:0000398 mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.42 0.80
Trophozoite possibly expressed 0.84 0.55
Schizont expressed 0.33 0.79
Gametocyte not expressed 0.67 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0723900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.763 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0621400)

  • Relative Growth Rate: 0.79 ± 0.24
  • Confidence: 4.22

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0621400)

Modification: Disrupted | RMgm-2152

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBL4

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.01) with 2BVL (Global RMSD=25.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171493

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 46 24 72
disruptive 42 152 89 222
missense 20 131 80 190

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 111 40 103
disruptive 76 363 201 416
missense 40 286 149 277

PlasmoDB Total SNPs: 260

Non-coding: 153 | Synonymous: 64 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 1222 | Molecular Weight (kDa): 144.628

UniProt ID(s): Q8IBL4

PDB ID(s): None

Isoelectric Point: 6.59

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0