PF3D7_0724000

Genome location: Pf3D7_07_v3:1,006,222..1,012,279(+)

Genome classification: Core

Function and Localization

Product Description: Rab GTPase activator and protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005952	cAMP-dependent protein kinase complex
Function	GO:0004691	cAMP-dependent protein kinase activity
Process	GO:0018105	peptidyl-serine phosphorylation
Process	GO:0007165	signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.46	0.74
Schizont	possibly expressed	0.33	0.80
Gametocyte	possibly expressed	0.45	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0724000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.09 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4P1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532798

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	70	56	117
disruptive	60	212	141	355
missense	41	182	122	294

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	179	82	137
disruptive	144	586	247	554
missense	76	435	196	363

PlasmoDB Total SNPs: 171

Non-coding: 16 | Synonymous: 94 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 1936 | Molecular Weight (kDa): 234.488

UniProt ID(s): C0H4P1

PDB ID(s): None

Isoelectric Point: 9.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011009	Protein kinase-like domain superfamily
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	N/A	N/A
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily
Superfamily	SSF56112	Protein kinase-like domain superfamily