Genome location: Pf3D7_07_v3:1,019,248..1,020,817(-)
Genome classification: Core
Product Description: type 2A phosphatase-associated protein 42, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0051721 | protein phosphatase 2A binding |
| Process | GO:0035303 | regulation of dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.21 | 0.90 |
| Trophozoite | possibly expressed | 0.39 | 0.77 |
| Schizont | not expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0724200
Resistome Missense Mutations: V148I
Resistome Compounds with Missense Mutations: MMV665794
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.143 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBL0
"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=13.77) with 7WM6 (Global RMSD=14.07)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102570
Most Similar Human Ortholog: A0A1W2PR95
TM-align score: 0.61 | RMSD: 4.89
Seq Identity: 0.17 | Length: 267 / 427
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000089289 | immunoglobulin binding protein 1 |
| ENSG00000266826 | immunoglobulin (CD79A) binding protein 1 pseudogene 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 24 | 13 | 16 |
| disruptive | 10 | 54 | 28 | 63 |
| missense | 6 | 49 | 25 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 41 | 9 | 27 |
| disruptive | 19 | 117 | 52 | 111 |
| missense | 15 | 88 | 39 | 74 |
PlasmoDB Total SNPs: 34
Non-coding: 11 | Synonymous: 13 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 427 | Molecular Weight (kDa): 51.569
UniProt ID(s): Q8IBL0
PDB ID(s): None
Isoelectric Point: 6.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007304 | TAP46-like protein |
| PFam | PF04177 | TAP46-like protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27549441 | Effects of nitrogen availability on polymalic acid biosynthesis in the yeast-likefungus Aureobasidium pullulans | Wang Y, Song X, ..., Zou X | 10.1186/s12934-016-0547-y |
| 25512609 | TORC1 inhibition induces lipid droplet replenishment in yeast | Madeira JB, Masuda CA, ..., Bozaquel-Morais BL | 10.1128/MCB.01314-14 |
| 28976047 | Target of rapamycin complex 1 and Tap42-associated phosphatases are required forsensing changes in nitrogen conditions in the yeast Saccharomyces cerevisiae | Li J, Yan G, ..., Jiang Y | 10.1111/mmi.13858 |
| 24970820 | Insights from yeast into whether the inhibition of heat shock transcriptionfactor (Hsf1) by rapamycin can prevent the Hsf1 activation that results fromtreatment with an Hsp90 inhibitor | Millson SH, Piper PW | 10.18632/oncotarget.2077 |
| 24474773 | Deletion of conserved protein phosphatases reverses defects associated withmitochondrial DNA damage in Saccharomyces cerevisiae | Garipler G, Mutlu N, Lack NA, Dunn CD | 10.1073/pnas.1312399111 |
| 26466677 | Target of rapamycin signaling mediates vacuolar fission caused by endoplasmicreticulum stress in Saccharomyces cerevisiae | Stauffer B, Powers T | 10.1091/mbc.E15-06-0344 |
| 30335186 | TORC1-signalling is down-regulated in Saccharomyces cerevisiae hsp30Delta cells bySNF1-dependent mechanisms | Singh A, Chowdhury D, ..., Chakrabarti A | 10.1002/yea.3360 |
| 33957926 | TORC1 regulates the transcriptional response to glucose and developmental cyclevia the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae | Alfatah M, Wong JH, ..., Arumugam P | 10.1186/s12915-021-01030-3 |
| 27343235 | Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Throughthe Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation | Workman JJ, Chen H, Laribee RN | 10.1534/genetics.116.188458 |