PF3D7_0724500

Genome location: Pf3D7_07_v3:1,024,663..1,026,167(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.27	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0724500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.285 | MFS: -3.4 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0622000)

Relative Growth Rate: 1.00 ± 0.14
Confidence: 5.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0622000)

Modification: Disrupted | RMgm-2154

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBK7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533443

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	17	5	14
disruptive	5	22	16	46
missense	5	22	16	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	32	6	15
disruptive	7	58	32	82
missense	6	53	24	57

PlasmoDB Total SNPs: 99

Non-coding: 77 | Synonymous: 15 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 304 | Molecular Weight (kDa): 36.593

UniProt ID(s): Q8IBK7

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A