About Gene List

PF3D7_0724600

Genome location: Pf3D7_07_v3:1,026,103..1,033,815(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:1903561 extracellular vesicle
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.12 0.94
Trophozoite expressed 0.58 0.67
Schizont expressed 0.45 0.73
Gametocyte expressed 0.43 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0724600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.997 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBK6

"Best" AlphaFill ligand hit: STU (staurosporine, Local RMSD=1.65) with 2CLQ (Global RMSD=4.12)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.11.1 non-specific serine/threonine protein kinase ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532872

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 87 58 108
disruptive 77 272 175 400
missense 39 193 134 274

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 189 85 128
disruptive 148 721 277 672
missense 74 470 201 420

PlasmoDB Total SNPs: 350

Non-coding: 108 | Synonymous: 144 | Nonsynonymous: 98 | Stop Codon: 0

Protein Information

Protein Length: 2041 | Molecular Weight (kDa): 243.554

UniProt ID(s): Q8IBK6

PDB ID(s): None

Isoelectric Point: 8.26

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain superfamily
PFam N/A N/A
Superfamily SSF56112 Protein kinase-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
33608523 20S proteasomes secreted by the malaria parasite promote its growth. Dekel E, Yaffe D, ..., Regev-Rudzki N 10.1038/s41467-021-21344-8