Product Description: protein kinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:1903561 | extracellular vesicle |
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | possibly expressed | 0.12 | 0.94 |
Trophozoite | expressed | 0.58 | 0.67 |
Schizont | expressed | 0.45 | 0.73 |
Gametocyte | expressed | 0.43 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0724600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.997 | #Insertions: 9
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBK6
"Best" AlphaFill ligand hit: STU (staurosporine, Local RMSD=1.65) with 2CLQ (Global RMSD=4.12)
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 16 | 87 | 58 | 108 |
disruptive | 77 | 272 | 175 | 400 |
missense | 39 | 193 | 134 | 274 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 35 | 189 | 85 | 128 |
disruptive | 148 | 721 | 277 | 672 |
missense | 74 | 470 | 201 | 420 |
PlasmoDB Total SNPs: 350
Non-coding: 108 | Synonymous: 144 | Nonsynonymous: 98 | Stop Codon: 0
Protein Length: 2041 | Molecular Weight (kDa): 243.554
UniProt ID(s): Q8IBK6
PDB ID(s): None
Isoelectric Point: 8.26
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000719 | Protein kinase domain |
InterPro | IPR011009 | Protein kinase-like domain superfamily |
PFam | N/A | N/A |
Superfamily | SSF56112 | Protein kinase-like domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
33608523 | 20S proteasomes secreted by the malaria parasite promote its growth. | Dekel E, Yaffe D, ..., Regev-Rudzki N | 10.1038/s41467-021-21344-8 |