Genome location: Pf3D7_07_v3:1,034,245..1,046,354(-)
Genome classification: Core
Product Description: bromodomain protein 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005667 | transcription regulator complex |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.14 | 0.51 |
| Trophozoite | expressed | 1.25 | 0.40 |
| Schizont | expressed | 0.45 | 0.75 |
| Gametocyte | expressed | 1.07 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0724700
Resistome Missense Mutations: N1678K
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.153 | MFS: -2.825 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 134 | 85 | 203 |
| disruptive | 99 | 365 | 200 | 532 |
| missense | 57 | 283 | 165 | 418 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 46 | 289 | 129 | 211 |
| disruptive | 226 | 828 | 348 | 831 |
| missense | 107 | 610 | 259 | 533 |
PlasmoDB Total SNPs: 563
Non-coding: 195 | Synonymous: 184 | Nonsynonymous: 184 | Stop Codon: 0
Protein Length: 3489 | Molecular Weight (kDa): 420.676
UniProt ID(s): C0H4P2
PDB ID(s): None
Isoelectric Point: 8.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR038841 | Uncharacterized protein PF07_0086 |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |