PF3D7_0725100

Genome location: Pf3D7_07_v3:1,064,276..1,070,581(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	possibly expressed	0.54	0.69
Schizont	not expressed	0.50	0.69
Gametocyte	possibly expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0725100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.078 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBK0

"Best" AlphaFill ligand hit: OCT (n-octane, Local RMSD=0.19) with 6JO0 (Global RMSD=19.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533541

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	68	36	63
disruptive	194	252	132	284
missense	97	214	116	241

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	124	47	80
disruptive	253	521	201	388
missense	131	426	161	258

PlasmoDB Total SNPs: 403

Non-coding: 129 | Synonymous: 94 | Nonsynonymous: 180 | Stop Codon: 0

Protein Information

Protein Length: 1576 | Molecular Weight (kDa): 190.799

UniProt ID(s): Q8IBK0

PDB ID(s): None

Isoelectric Point: 9.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A