PF3D7_0725200

Genome location: Pf3D7_07_v3:1,070,594..1,072,029(+)

Genome classification: Core

Function and Localization

Product Description: mago nashi protein homologue, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0035145	exon-exon junction complex
Process	GO:0008380	RNA splicing
Process	GO:0007530	sex determination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.16	0.90
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0725200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.167 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0622700)

Relative Growth Rate: 0.16 ± 0.05
Confidence: 7.37

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0622700)

Modification: Disrupted | RMgm-2157

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBJ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102299

Most Similar Human Ortholog: P61326

TM-align score: 0.94 | RMSD: 1.24

Seq Identity: 0.71 | Length: 143 / 148

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000111196	mago homolog B, exon junction complex subunit
ENSG00000162385	mago homolog, exon junction complex subunit

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	3	7
disruptive	0	2	2	4
missense	0	2	2	4

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	9	4	11
disruptive	0	7	8	15
missense	0	6	6	13

PlasmoDB Total SNPs: 106

Non-coding: 103 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 148 | Molecular Weight (kDa): 17.599

UniProt ID(s): Q8IBJ9

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004023	Mago nashi protein
InterPro	IPR036605	Mago nashi superfamily
PFam	PF02792	Mago nashi protein
Superfamily	SSF89817	Mago nashi superfamily