PF3D7_0725300

Genome location: Pf3D7_07_v3:1,071,985..1,075,144(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0005634	nucleus
Component	GO:0030687	preribosome, large subunit precursor
Process	GO:0042273	ribosomal large subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.47	0.77
Trophozoite	expressed	0.33	0.82
Schizont	expressed	0.19	0.90
Gametocyte	possibly expressed	0.24	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0725300

Resistome Missense Mutations: S525I

Resistome Compounds with Missense Mutations: MMV675939

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 6 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.223 | MFS: -2.714 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0622800)

Relative Growth Rate: 0.09 ± 0.11
Confidence: 5.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBJ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171476

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	33	21	40
disruptive	31	121	50	138
missense	12	91	44	105

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	69	28	46
disruptive	52	225	84	171
missense	24	167	65	131

PlasmoDB Total SNPs: 167

Non-coding: 35 | Synonymous: 84 | Nonsynonymous: 47 | Stop Codon: 1

Protein Information

Protein Length: 793 | Molecular Weight (kDa): 93.452

UniProt ID(s): Q8IBJ8

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
InterPro	IPR037379	WDR74/Nsa1
PFam	N/A	N/A
Superfamily	SSF50998	Quinoprotein alcohol dehydrogenase-like superfamily

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108