PF3D7_0725400

Genome location: Pf3D7_07_v3:1,078,691..1,080,123(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MCFLKYFIFSLIWIFLYNEKAKD

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.79	0.77
Trophozoite	expressed	0.09	0.95
Schizont	expressed	0.95	0.66
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0725400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -3.651 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBJ7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533441

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	3	3	3
disruptive	2	6	2	12
missense	2	6	2	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	7	3	5
disruptive	8	11	11	35
missense	6	5	6	18

PlasmoDB Total SNPs: 82

Non-coding: 75 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 109 | Molecular Weight (kDa): 13

UniProt ID(s): Q8IBJ7

PDB ID(s): None

Isoelectric Point: 10.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A