PF3D7_0726400

Genome location: Pf3D7_07_v3:1,108,583..1,125,415(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0017108	5'-flap endonuclease activity
Function	GO:0048256	flap endonuclease activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.73	0.68
Trophozoite	possibly expressed	1.51	0.34
Schizont	expressed	1.30	0.45
Gametocyte	not expressed	1.50	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0726400

Resistome Missense Mutations: K4488N

Resistome Compounds with Missense Mutations: MMV665852

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.875 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532713

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	48	246	147	308
disruptive	197	834	449	1070
missense	138	721	404	907

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	79	503	230	364
disruptive	401	1815	736	1518
missense	255	1481	585	1036

PlasmoDB Total SNPs: 690

Non-coding: 219 | Synonymous: 233 | Nonsynonymous: 236 | Stop Codon: 2

Protein Information

Protein Length: 4944 | Molecular Weight (kDa): 599.324

UniProt ID(s): C0H4P4

PDB ID(s): None

Isoelectric Point: 7.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006084	XPG/Rad2 endonuclease
InterPro	IPR032641	Exonuclease 1
PFam	N/A	N/A
Superfamily	N/A	N/A