Product Description: ubiquitin carboxyl-terminal hydrolase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.19.12 (Ubiquitinyl hydrolase 1)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0004197 | cysteine-type endopeptidase activity |
| Function | GO:0004843 | thiol-dependent deubiquitinase |
| Process | GO:0016579 | protein deubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.98 | 0.58 |
| Trophozoite | expressed | 1.75 | 0.26 |
| Schizont | expressed | 1.01 | 0.54 |
| Gametocyte | expressed | 2.06 | 0.20 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0726500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.26 | MFS: -2.656 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0210600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.19.12 | ubiquitinyl hydrolase 1 | KClNEMDTTEDTAEGTARNAisiRNApeptidesAntibodyubiquitinLDN-574442-propenal... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q96K76 | Ubiquitin carboxyl-terminal hydrolase 47 | Homo sapiens | OrthoDB | CHEMBL2159495CHEMBL2159497CHEMBL2159498CHEMBL2159499... |
| Q93009 | Ubiquitin carboxyl-terminal hydrolase 7 | Homo sapiens | OrthoDB | US10836741, Example I-5US10836741, Example I-2US10836741, Example I-3US10836741, Example I-4... |
Ortholog Group (OrthoMCL): OG6_101317
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3183
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000187555 | ubiquitin specific peptidase 7 |
Protein Length: 3183 | Molecular Weight (kDa): 373.169
UniProt ID(s): Q8IBJ1
PDB ID(s): None
Isoelectric Point: 7.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| InterPro | IPR002083 | MATH/TRAF domain |
| InterPro | IPR008974 | TRAF-like |
| InterPro | IPR018200 | Ubiquitin specific protease, conserved site |
| InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| PFam | PF00443 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Superfamily | SSF49599 | TRAF-like |
| Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 47 | 202 | 101 | 237 |
| disruptive | 149 | 423 | 238 | 569 |
| missense | 76 | 301 | 193 | 441 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 80 | 383 | 140 | 227 |
| disruptive | 261 | 863 | 398 | 910 |
| missense | 132 | 626 | 308 | 609 |
PlasmoDB Total SNPs: 588
Non-coding: 221 | Synonymous: 222 | Nonsynonymous: 145 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |