PF3D7_0726600

Genome location: Pf3D7_07_v3:1,139,818..1,143,059(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.25	0.84
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.28	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0726600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.16 | MFS: -2.822 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBJ0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533365

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	36	18	40
disruptive	15	82	58	133
missense	12	62	54	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	78	28	50
disruptive	40	211	109	201
missense	27	174	90	129

PlasmoDB Total SNPs: 210

Non-coding: 150 | Synonymous: 40 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 688 | Molecular Weight (kDa): 81.278

UniProt ID(s): Q8IBJ0

PDB ID(s): None

Isoelectric Point: 6.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A