PF3D7_0726700

Genome location: Pf3D7_07_v3:1,143,196..1,143,923(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKIFLLCFALLFVPYKCLI

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.49	0.72
Schizont	not expressed	0.51	0.70
Gametocyte	possibly expressed	0.69	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0726700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.308 | MFS: -3.436 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBI9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532730

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	4	13
disruptive	1	9	5	22
missense	1	9	5	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	16	10	18
disruptive	3	27	21	36
missense	3	23	16	28

PlasmoDB Total SNPs: 21

Non-coding: 15 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 170 | Molecular Weight (kDa): 20.395

UniProt ID(s): Q8IBI9

PDB ID(s): None

Isoelectric Point: 10.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A