PF3D7_0727100

Genome location: Pf3D7_07_v3:1,151,697..1,155,473(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.07	0.97
Trophozoite	expressed	0.44	0.73
Schizont	expressed	0.18	0.88
Gametocyte	expressed	0.31	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0727100

Resistome Missense Mutations: S837G, Q853R

Resistome Compounds with Missense Mutations: AN13762, AN13956, MMV665794

Resistome # Samples with Disruptive Mutations: 12 (11 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.368 | MFS: -2.49 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0211200)

Relative Growth Rate: 0.06 ± 0.03
Confidence: 8.24

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4P6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156427

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	48	24	48
disruptive	85	185	83	194
missense	29	98	43	121

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	85	36	67
disruptive	138	344	144	323
missense	50	186	77	174

PlasmoDB Total SNPs: 297

Non-coding: 63 | Synonymous: 93 | Nonsynonymous: 138 | Stop Codon: 3

Protein Information

Protein Length: 1066 | Molecular Weight (kDa): 127.071

UniProt ID(s): C0H4P6

PDB ID(s): None

Isoelectric Point: 5.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A