PF3D7_0727500

Genome location: Pf3D7_07_v3:1,164,165..1,166,851(-)

Genome classification: Core

Function and Localization

Product Description: mTERF domain-containing protein, putative

SignalP Peptide: MNINVFFIILILIHVSTH

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.61	0.65
Schizont	expressed	0.18	0.89
Gametocyte	not expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0727500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -3.149 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0211600)

Relative Growth Rate: 0.22 ± 0.28
Confidence: 3.90

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBI2

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=15.67) with 8G64 (Global RMSD=19.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142580

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	50	18	46
disruptive	21	63	34	87
missense	19	60	34	78

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	80	30	54
disruptive	37	133	80	128
missense	29	117	75	99

PlasmoDB Total SNPs: 143

Non-coding: 98 | Synonymous: 27 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 707 | Molecular Weight (kDa): 86.187

UniProt ID(s): Q8IBI2

PDB ID(s): None

Isoelectric Point: 9.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003690	Transcription termination factor, mitochondrial/chloroplastic
PFam	PF02536	Transcription termination factor, mitochondrial/chloroplastic
Superfamily	N/A	N/A