PF3D7_0727600

Genome location: Pf3D7_07_v3:1,167,163..1,170,838(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.25	0.85
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0727600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.953 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A146M1S3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533011

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	59	38	75
disruptive	48	114	93	193
missense	40	108	85	179

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	113	46	82
disruptive	70	285	151	237
missense	55	249	131	188

PlasmoDB Total SNPs: 198

Non-coding: 85 | Synonymous: 53 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 1029 | Molecular Weight (kDa): 123.539

UniProt ID(s): A0A146M1S3

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A