PF3D7_0727700

Genome location: Pf3D7_07_v3:1,171,212..1,174,450(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	expressed	0.36	0.78
Schizont	expressed	0.13	0.92
Gametocyte	possibly expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0727700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.95 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0211800)

Relative Growth Rate: 0.15 ± 0.26
Confidence: 4.12

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBI0

"Best" AlphaFill ligand hit: BMF (bromosporine, Local RMSD=0.54) with 5U9N (Global RMSD=16.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533702

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	63	27	69
disruptive	46	196	100	203
missense	34	171	95	172

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	112	52	76
disruptive	91	390	129	273
missense	64	325	108	204

PlasmoDB Total SNPs: 177

Non-coding: 60 | Synonymous: 59 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 956 | Molecular Weight (kDa): 114.829

UniProt ID(s): Q8IBI0

PDB ID(s): None

Isoelectric Point: 9.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A