PF3D7_0727900

Genome location: Pf3D7_07_v3:1,183,630..1,190,173(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005789	endoplasmic reticulum membrane
Component	GO:0005634	nucleus
Function	GO:0003700	DNA-binding transcription factor activity
Function	GO:0043565	sequence-specific DNA binding
Process	GO:0045893	positive regulation of transcription, DNA-templated
Process	GO:0016540	protein autoprocessing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.68	0.68
Trophozoite	not expressed	0.63	0.65
Schizont	not expressed	0.63	0.63
Gametocyte	not expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0727900

Resistome Missense Mutations: R789I

Resistome Compounds with Missense Mutations: GNF179/KAF179

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.726 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0212000)

Modification: Disrupted | RMgm-1723

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH8

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.06) with 6JWR (Global RMSD=13.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532372

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	118	58	139
disruptive	85	332	179	436
missense	47	252	152	348

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	56	234	94	140
disruptive	182	715	320	698
missense	105	525	259	402

PlasmoDB Total SNPs: 321

Non-coding: 66 | Synonymous: 146 | Nonsynonymous: 109 | Stop Codon: 0

Protein Information

Protein Length: 1923 | Molecular Weight (kDa): 230.435

UniProt ID(s): Q8IBH8

PDB ID(s): None

Isoelectric Point: 8.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012337	Ribonuclease H-like superfamily
PFam	N/A	N/A
Superfamily	SSF53098	Ribonuclease H-like superfamily