PF3D7_0728100

Genome location: Pf3D7_07_v3:1,193,347..1,210,448(-)

Genome classification: Core

Function and Localization

Product Description: anaphase-promoting complex subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005680	anaphase-promoting complex
Function	GO:0060090	molecular adaptor activity
Process	GO:0031145	anaphase-promoting complex-dependent catabolic process
Process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle
Process	GO:0070979	protein K11-linked ubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.94
Trophozoite	possibly expressed	1.16	0.47
Schizont	possibly expressed	0.70	0.67
Gametocyte	not expressed	1.44	0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -2.857 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533060

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	67	340	188	381
disruptive	344	985	568	1187
missense	204	779	474	1024

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	127	648	236	441
disruptive	591	1991	808	1507
missense	343	1541	669	1116

PlasmoDB Total SNPs: 763

Non-coding: 41 | Synonymous: 356 | Nonsynonymous: 366 | Stop Codon: 0

Protein Information

Protein Length: 5561 | Molecular Weight (kDa): 671.117

UniProt ID(s): Q8IBH6

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024990	Anaphase-promoting complex subunit 1
PFam	N/A	N/A
Superfamily	N/A	N/A