Genome location: Pf3D7_07_v3:1,211,209..1,213,613(+)
Genome classification: Core
Product Description: actin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.18 | 0.88 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0728200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.961 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0212300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0212300)
Modification: Disrupted | RMgm-1725
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBH5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 30 | 12 | 37 |
| disruptive | 7 | 63 | 29 | 74 |
| missense | 6 | 60 | 28 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 56 | 29 | 35 |
| disruptive | 19 | 121 | 58 | 133 |
| missense | 15 | 107 | 48 | 95 |
PlasmoDB Total SNPs: 113
Non-coding: 63 | Synonymous: 38 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 552 | Molecular Weight (kDa): 65.541
UniProt ID(s): Q8IBH5
PDB ID(s): None
Isoelectric Point: 5.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004000 | Actin family |
| InterPro | IPR027127 | Actin-related protein 10 |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00022 | Actin family |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 33836197 | Structural characterization and antioxidant activities of one neutralpolysaccharide and three acid polysaccharides from the roots of Arctium lappa L.:A comparison | Li L, Qiu Z, ..., Zheng Z | 10.1016/j.ijbiomac.2021.03.177 |
| 31202844 | Structural characterization and immunoregulatory activity of two polysaccharidesfrom the rhizomes of Atractylodes lancea (Thunb.) DC | Qin J, Wang HY, ..., Lv GP | 10.1016/j.ijbiomac.2019.06.088 |