PF3D7_0728300

Genome location: Pf3D7_07_v3:1,213,841..1,214,973(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.32	0.79
Schizont	expressed	0.13	0.90
Gametocyte	expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.466 | MFS: -2.619 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0212400)

Relative Growth Rate: 0.08 ± 0.07
Confidence: 6.62

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137119

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	18	5	17
disruptive	1	13	15	33
missense	1	12	12	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	30	9	15
disruptive	7	41	30	54
missense	2	33	22	41

PlasmoDB Total SNPs: 49

Non-coding: 35 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 211 | Molecular Weight (kDa): 25.34

UniProt ID(s): Q8IBH4

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A