PF3D7_0728400

Genome location: Pf3D7_07_v3:1,214,862..1,215,834(+)

Genome classification: Core

Function and Localization

Product Description: SDH5 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	not expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.831 | MFS: -4.024 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533199

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	5	13
disruptive	4	17	14	20
missense	4	17	14	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	17	2	20
disruptive	4	34	19	33
missense	4	31	17	25

PlasmoDB Total SNPs: 55

Non-coding: 46 | Synonymous: 2 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 126 | Molecular Weight (kDa): 15.142

UniProt ID(s): Q8IBH3

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005631	Flavinator of succinate dehydrogenase
InterPro	IPR036714	Flavinator of succinate dehydrogenase superfamily
PFam	PF03937	Flavinator of succinate dehydrogenase
Superfamily	SSF109910	Flavinator of succinate dehydrogenase superfamily