PF3D7_0728500

Genome location: Pf3D7_07_v3:1,216,088..1,217,201(-)

Genome classification: Core

Function and Localization

Product Description: EF hand domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.12	0.92
Schizont	no data	0.09	0.94
Gametocyte	no data	0.64	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.987 | MFS: -1.644 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4P8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533431

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	5	9
disruptive	4	19	10	31
missense	4	17	10	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	19	3	9
disruptive	12	40	18	31
missense	9	34	16	26

PlasmoDB Total SNPs: 84

Non-coding: 70 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 143 | Molecular Weight (kDa): 17.134

UniProt ID(s): C0H4P8

PDB ID(s): None

Isoelectric Point: 6.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011992	EF-hand domain pair
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair