PF3D7_0728600

Genome location: Pf3D7_07_v3:1,217,404..1,225,908(+)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.80	0.61
Schizont	expressed	0.82	0.61
Gametocyte	expressed	1.64	0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728600

Resistome Missense Mutations: S1660R

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.317 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102297

Most Similar Human Ortholog: D6RFK1

TM-align score: 0.84 | RMSD: 1.25

Seq Identity: 0.04 | Length: 51 / 2162

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000145916	required for meiotic nuclear division 5 homolog B
ENSG00000153561	required for meiotic nuclear division 5 homolog A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	131	60	127
disruptive	133	381	192	399
missense	61	304	165	318

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	242	90	122
disruptive	228	720	278	537
missense	113	555	223	369

PlasmoDB Total SNPs: 542

Non-coding: 210 | Synonymous: 181 | Nonsynonymous: 151 | Stop Codon: 0

Protein Information

Protein Length: 2162 | Molecular Weight (kDa): 253.974

UniProt ID(s): Q8IBH2

PDB ID(s): None

Isoelectric Point: 8.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
InterPro	IPR027370	RING-type zinc-finger, LisH dimerisation motif
InterPro	IPR038841	Uncharacterized protein PF07_0086
PFam	PF13445	RING-type zinc-finger, LisH dimerisation motif
Superfamily	SSF57850	N/A