PF3D7_0728700

Genome location: Pf3D7_07_v3:1,225,499..1,229,857(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Function	GO:0016298	lipase activity
Function	GO:0008474	palmitoyl-(protein) hydrolase activity
Process	GO:0006629	lipid metabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.05	0.97
Gametocyte	expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.242 | MFS: -2.59 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110414

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	34	29	41
disruptive	14	91	47	121
missense	11	87	46	107

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	67	32	45
disruptive	34	212	85	175
missense	23	177	73	134

PlasmoDB Total SNPs: 175

Non-coding: 122 | Synonymous: 37 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 720 | Molecular Weight (kDa): 84.807

UniProt ID(s): Q8IBH1

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	N/A	N/A
Superfamily	SSF53474	Alpha/Beta hydrolase fold