PF3D7_0728800

Genome location: Pf3D7_07_v3:1,230,145..1,232,666(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MICLIFYVLFVLLLQDIIIW

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.15	0.93
Trophozoite	expressed	1.08	0.45
Schizont	expressed	0.25	0.85
Gametocyte	possibly expressed	0.65	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.068 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0212900)

Relative Growth Rate: 0.09 ± 0.07
Confidence: 6.83

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBH0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533643

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	21	12	25
disruptive	29	72	35	98
missense	17	63	32	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	43	13	29
disruptive	51	142	53	146
missense	31	122	45	100

PlasmoDB Total SNPs: 181

Non-coding: 142 | Synonymous: 17 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 466 | Molecular Weight (kDa): 55.748

UniProt ID(s): Q8IBH0

PDB ID(s): None

Isoelectric Point: 7.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A