PF3D7_0728900

Genome location: Pf3D7_07_v3:1,232,210..1,235,443(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005686	U2 snRNP
Component	GO:0005684	U2-type spliceosomal complex
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.61	0.73
Trophozoite	no data	1.07	0.46
Schizont	no data	0.30	0.82
Gametocyte	no data	0.77	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0728900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.213 | MFS: -2.717 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0213000)

Relative Growth Rate: 0.03 ± 0.05
Confidence: 7.49

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4P9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102631

Most Similar Human Ortholog: Q5H918

TM-align score: 0.53 | RMSD: 5.02

Seq Identity: 0.22 | Length: 194 / 492

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000102241	HIV-1 Tat specific factor 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	30	21	32
disruptive	12	70	34	92
missense	12	62	33	76

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	52	20	36
disruptive	29	150	71	145
missense	20	128	60	95

PlasmoDB Total SNPs: 190

Non-coding: 141 | Synonymous: 28 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 492 | Molecular Weight (kDa): 58.32

UniProt ID(s): C0H4P9

PDB ID(s): None

Isoelectric Point: 7.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR034392	TatSF1-like, RNA recognition motif 1
InterPro	IPR034393	TatSF1-like
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily